Research scientists are exploring new physiological pathways and new therapeutics to regulate glucose in people living with type 2 diabetes. Studies have shown that fibroblast growth factor 21 (FGF-21) has the ability to regulate blood glucose levels; however, these effects are temporary. In another promising development, activation of the fibroblast growth factor receptor-1 (FGFR-1) using a specifically designed antibody has shown to be effective in regulating glucose and is capable of long residence times in the blood. Scientists are also exploring the role of FGF-1, another member of the FGF family, in fat remodeling and glucose regulation. It is possible that the regulation of blood glucose levels by FGF-1 might actually involve regulation of a neural pathway (as opposed to a systemic metabolic pathway). People living with diabetes can have hope that scientists are close to developing novel therapeutics to regulate glucose over an extended period of time.
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